Ghost in the Shell is an anime that has already attained classic status. It merges the potential for beautiful visualization with a powerful storyline exploring philosophical questions. The resulting mix is a very impressive experience, and undoubtedly one of the best examples of the anime art form.
The original dialog is, of course, in Japanese. The translation has some awkardness and occasionally renders the details of the plot hard to follow, but not in a manner that detracts from the really interesting element: exploring the idea of the soul in a world where humans are gradually replacing more and more of their bodies with machines, and even brains can be hacked and reprogrammed.
This is definitely not an anime for the light-hearted and carefree. I highly recommend it.